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Proven solution - findings of clinical research studies

Aerosure Medic is a drug-free, Class 1 respiratory device that has been shown to reduce breathlessness. Below are some of the research studies that have been carried out with both Aerosure and the technology it uses, IMT and Oscillatory PEP. EMS is a widely used and well recognised technology that has been shown to help with the symptoms associated with breathlessness and the relief of symptoms associated with some medical conditions (such as COPD).

Improving inspiratory muscle strength in COPD using IMT

A controlled study analysed the effects of IMT on exercise capacity, dyspnea, and inspiratory fraction during exercise in patients with COPD. Daily inspiratory muscle strength and endurance training were performed for 8 weeks in patients with COPD. Results showed an increase in muscle strength following IMT, as well as an increase in inspiratory fraction, suggesting a reduction in dynamic hyperinflation. Other findings were improved breathing pattern and decreased perception of dyspnea. These outcomes were not achieved in the control group.

Petrovic, M., Reiter, M., Zipko, H., Pohl, W., & Wanke, T. (2012). Effects of inspiratory muscle training on dynamic hyperinflation in patients with COPD. Int J Chron Obstruct Pulmon Dis, 7, 797-805.

In another study, COPD patients were randomised into a group that received IMT for one year, or a control group that received IMT training but with a very low load. Results showed a statistically significant increase in inspiratory muscle strength, 6-minute walk distance, Borg score and health-related quality of life scores in the IMT group but not in the control group. The changes were maintained at the end of the year.

Beckerman, M., Magadle, R., Weiner, M., & Weiner, P. (2005). The effects of 1 year of specific inspiratory muscle training in patients with COPD. CHEST Journal, 128(5), 3177-3182.

The aim of a further study was to determine the relative value of different tests in detecting changes in inspiratory muscle endurance following inspiratory muscle training in COPD. Subjects were randomised to either IMT or sham IMT training three times per week for 8 weeks. Changes in inspiratory muscle endurance observed in the IMT group were greater than baseline and also compared to the sham IMT group.

Hill, K., Jenkins, S. C., Philippe, D. L., Shepherd, K. L., Hillman, D. R., & Eastwood, P. R. (2007). Comparison of incremental and constant load tests of inspiratory muscle endurance in COPD. European Respiratory Journal, 30(3), 479-486.

Improving inspiratory muscle strength in healthy subjects using IMT

This study investigated whether breathing against a vibration stimulus would elicit increments of spontaneous and maximal inspiratory mouth pressure and tidal mean inspiratory flow upon stimulus removal. Healthy subjects performed 3 maximal inspirations before and after 10 inspirations against a resistive vibration-type load stimulus, a resistive breathing stimulus and a control with no load, in a random order. Only the resistive vibration-type stimulus increased tidal and maximum mouth pressure. Mean inspiratory flow also increased with the resistive vibration-type stimulus.

Sumners, D. P., Green, D. A., Mileva, K. N., & Bowtell, J. L. (2008). Increases in inspiratory neural drive in response to rapid oscillating airflow braking forces (vibration). Respiratory physiology & neurobiology, 160(3), 350-352.

Improved chest clearance in cystic fibrosis

This study investigated the effectiveness of a PEP chest clearance device in comparison to standard PEP mask therapy. Participants with cystic fibrosis were admitted to hospital for a respiratory exacerbation where they were randomised to either the chest clearance device or mask treatment group. Both groups completed two treatment sessions per day for ten days. At the end of the study period there were no statistically significant differences between groups for any outcome measure and participants were satisfied with both treatments. The results suggest that there is no statistically significant difference between the PEP chest clearance device and the standard PEP mask for use during an acute exacerbation.

West, K., Wallen, M., & Follett, J. (2010). Acapella vs. PEP mask therapy: a randomised trial in children with cystic fibrosis during respiratory exacerbation. Physiotherapy theory and practice, 26(3), 143-149.

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